The autopsy performed on Hugh Hefner’s body revealed a pair of strange factors that contributed to his death. According to TMZ, the cardiac arrest and respiratory failure that stopped his heart were caused, at least in part, by a condition called septicemia, which causes extreme inflammation of the body tissues as a result of an infection circulating in the blood stream. That infection may have been the E. coli that was also detected in his system. According to Johns Hopkins Medicine, E. coli is one of the three bacteria that most commonly cause septicemia, which, without prompt treatment, can rapidly result in tissue damage, organ failure, and, in worst-case scenarios, death. The death certificate said that the strain of E. coli found in Hefner’s body was “highly resistant to antibiotics” and that it was of “undetermined etiology,” meaning the medical examiner was unable to ascertain where he had contracted the deadly bacteria.

One possible source of the germs may have been Hef’s very own home. Once the world capital of devil-may-care hedonism, the Playboy Mansion had notoriously fallen into ruin toward the end of Hefner’s life. According to The Sun, a 2011 investigation by the Los Angeles County Department of Public Health found that the swimming pools contained the bacteria that causes Legionnaire’s disease after over 120 people got sick at a party there. It appears that Hefner’s youthful spirit was likely no match for his bad hygiene.

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