Experts found a link between vitamin D - immunocompetence & aging

Experts found a link between vitamin D – immunocompetence & aging – Vitamin D goes beyond bone health: While well-known for its role in calcium absorption and bone health, vitamin D also significantly impacts our immune system. This review explores how vitamin D’s influence on immunocompetence (our ability to fight off infections) changes with age.

As we age, our immune system becomes less effective, making us more prone to infections and diseases. This decline, called “immunocompetence,” involves changes in immune cell function and the thymus, which produces T lymphocytes.

Vitamin D acts like a hormone, binding to a specific receptor (VDR) in immune cells. This activates genes important for immune function. Interestingly, individual responses to vitamin D vary due to genetic and epigenetic factors.

Several studies have reported an association between vitamin D, immunocompetence, and aging. Vitamin D deficiency has been linked to an increased risk of numerous diseases and accelerated aging. It is also associated with an increased susceptibility to infection and autoimmunity. Vitamin D plays a central role in immunologic function, affecting immune cell proliferation, differentiation, and immunoglobulin secretion. As a result, vitamin D deficiency may have implications for immunocompetence and overall health in aging individuals. The research suggests that maintaining adequate vitamin D levels is important for supporting immunocompetence, particularly in the context of aging.

lifestyles for adequate vitamin D intake

Sun exposure:

  • Spend moderate time outdoors: Aim for 15-30 minutes of midday sun exposure, several times a week, on exposed skin (arms, legs, back). Adjust timing based on your location and skin type to avoid sunburn.
  • Consider latitude and season: Sun exposure effectiveness varies depending on your location and time of year. Generally, midday sun in spring and summer provides the most Vitamin D.
  • Balance sun exposure with sun safety: Apply sunscreen with SPF 30 or higher to protect against harmful UV rays, especially if you have fair skin or burn easily.


  • Eat vitamin D-rich foods: Include oily fish like salmon, sardines, tuna, mackerel, and herring in your diet. Other sources include egg yolks, cod liver oil, fortified milk, orange juice, and some mushrooms.
  • Check fortification: Many foods like cereals, milk, and yogurt are fortified with vitamin D. Read labels carefully to choose options with higher vitamin D content.


  • Consult your doctor: Discuss your individual needs and risk factors for vitamin D deficiency with your doctor. They can help determine if supplementation is necessary and recommend the appropriate dosage.
  • Follow safe recommendations: Do not exceed recommended daily intake levels of vitamin D without consulting your doctor. Excessive intake can lead to toxicity.

Additional factors:

  • Skin pigmentation: Individuals with darker skin tones may require more sun exposure or higher supplementation due to lower natural vitamin D production.
  • Clothing: Covering most of your skin while outdoors reduces vitamin D synthesis.
  • Medical conditions: Certain medical conditions can affect vitamin D absorption. Consult your doctor if you have concerns.

The researchers propose a personalized approach to vitamin D supplementation, taking into account individual responsiveness. They suggest a daily dose of 1 µg (40 IU)/kg body mass, exceeding general recommendations but staying within safe limits.

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